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Inadequate/Substantial Metabolizers, CYP2D6 The development of the Energetic metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Approximately seven% of the population has lowered activity on the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme method. These persons are “weak metabolizers” of debrisoquine, dextromethorphan and t